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序 列 ： The synthetic peptide used to raise the antibody Cat. No. 250456 is selected from a sequence within the N-term region of human ADAM-TS7. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. |
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分 子 量 ： 1319.5 g/mol |
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纯 度 ：Purity > 80% by HPLC
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形 态 ：Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect.
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溶 解： Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
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保存条件 ：Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
| 别 名 ：A disintegrin and metalloproteinase with thrombospondin motifs 7; ADAMTS-7; ADAM-TS 7; ADAM-TS7; COMPase; ADAMTS7 |
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产品描述 ：A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. |
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产品链接 ：http://www.ABBIOTEC.com/peptides/adam-ts7-peptide
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