IFIT3 Antibody_华拓生物

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IFIT3 Antibody

产品名称 ： IFIT3 Antibody

中文名称 ：干扰素诱导的三角形四肽重复蛋白3抗体

产品类别 ：一抗

品　　牌 ： PLLABS

货　　号 ： PL0505144

规　　格 ： 0.1ml(100ug/200ul)

详细信息

克隆类型：	Rabbit Polyclonal IgG
免疫原：	Recombinant fragment corresponding to 271-480aa of human IFIT3.
纯化方式：	Immunogen affinity purified
缓冲液：	PBS, pH 7.4(1%BSA and 0.1% Sodium azide)
产品描述：	IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21.
适用物种：	Hu, Mo, Rat
应用说明：	WB: 1:200-1:1000 E: 1:20000-1:80000 IHC: 1:100-1:500
别　　名：	CIG-49; GARG-49; IFI60; IFIT4; IRG2; ISG60; P60; RIG-G; cig41;
保存条件：	Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted.
标记物：	PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体
产品说明：

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