| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encomassing a sequence within the C-term region of human EGFR isoform 3. |
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产品描述 ： |
Epidermal growth factor receptor (EGFR) is a receptor for EGF and for various members of the EGF family such as TGF-alpha, amphiregulin, betacellulin, heparin-binding EGF-like growth factor, GP30 and vaccinia virus growth factor. EGFR is involved in the control of cell growth and differentation. Binding of EGF to the receptor leads to dimerization, internalization of the EGF-receptor complex, induction of the tyrosine kinase activity, stimulation of cell DNA synthesis and cell proliferation. EGFR isoform 3 (sEGFR, p110) is a 77 kDa isoform consisting of the extracellular EGFR domain and a unique, truncated carboxy terminus region without transmembrane domain. EGFR isoform 3 is being investigated as a marker for epithelial ovarian cancer. This antibody is specific for isoform 3, it will not recognized full-length EGFR and EGFR vIII. |
| 适用物种 ： |
H |
|
应用范围 ： |
E, WB |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:200-1:500 |
| 别 名 ： |
Epidermal growth factor receptor; receptor tyrosine-protein kinase erbB-1; p110; ERBB1l; EGFR isoform 3 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/egfr-isoform-3 |
| 标 记 物 ： |
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产品说明 ： |
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