| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
Mouse IgG2a |
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免 疫 原 ： |
Gliadin-related peptide (alpha-gliadin aa58-73, KLQPFPQPELPYPQPQ) coupled to immunogenic carrier protein PPD (tuberculin). |
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产品描述 ： |
Celiac disease is associated with a CD4+ T-cell response to epitopes of gliadin presented by HLA-DQ2 or -DQ8 class II MHC molecules. These epitopes are present in a 33-mer peptide of wheat alpha-gliadin, residues 56-88, which is resistant to digestion and forms a substrate for tissue transglutaminase (TG2), generating the glutamic acid residues essential for binding to HLA-DQ2. The immunogen corresponds to a deamidated form of a region that includes the T-cell epitopes, including the immunodominant PQPQLPY region and two PXPQP motifs associated with binding to IgA from patients with celiac disease. Complete homology exists between residues 63-73, 70-80 and 77-87 of wheat alpha gliadin. This antibody reacts strongly with the deamidated peptide but cross-reacts about 5% with the non-deamidated peptide KLQPFPQPQLPYPQPQ |
| 适用物种 ： |
Pl |
|
应用范围 ： |
E |
| 应用说明 ： |
Product Cat. No. 250437 reacts in ELISA with both the deamidated gliadin-related peptide (KLQPFPQPELPYPQPQ) and non-deamidated gliadin-related peptide (KLQPFPQPQLPYPQPQ) coated directly in microplate. The signal for the deamidated gliadin-related peptide is 20-fold higher. E: 1:64,000 |
| 别 名 ： |
Alpha gliadin; prolamin |
|
形 态 ： |
Each vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography. |
| 保存条件 ： |
Store at 4°C. Product is guaranteed 6 months from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/gliadin-peptide-14d5-antibody |
| 标 记 物 ： |
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产品说明 ： |
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