| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the center region of human p38 alpha MAPK. |
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产品描述 ： |
p38 alpha MAPK (Mitogen-activated protein kinase 14; SAPK2A) is activated by environmental stressors, pro-inflammatory cytokines and lipopolysaccharide. In turn it phosphorylates various transcription factors including ELK1 and ATF2 and downstream kinases such as MAPKAPK2 and MAPKAPK5. p38 alpha MAPK is activated at the Thr-X-Tyr motif by the dual specificity kinases MAP2K3, MAP2K6 and MAP2K4. In addition it can be phosphorylated by ATM or ATR upon DNA damage. It can be inhibited by dual specificity phosphatases such as DUSP1, and its kinase activity inhibited by pyridinyl-imidazole compounds that are cytokine-suppressive anti-inflammatory drugs (CSAID). |
| 适用物种 ： |
H, M, R, D |
|
应用范围 ： |
E, WB, IHC, IF |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500; IF: 1:100-1:500 |
| 别 名 ： |
p38 MAPK; Mitogen-activated protein kinase 14; Mitogen-activated protein kinase p38 alpha; MAP kinase p38 alpha; Cytokine suppressive anti-inflammatory drug-binding protein; CSAID-binding protein; CSBP; MAX-interacting-protein 2; MAP kinase MXI2; SAPK2A; MAPK14 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 0.1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/p38-alpha-mapk-antibody |
| 标 记 物 ： |
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产品说明 ： |
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