| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Fe65. |
|
产品描述 ： |
Fe65 (Amyloid beta A4 precursor protein-binding family B member 1) is an adaptor protein that forms a transcriptionally active complex with the gamma-secretase-derived amyloid precurson protein (APP) intracellular domain. APP functions as a cystosolic anchoring site that prevents Fe65 nuclear translocation. Following exposure to DNA damaging agents, Fe65 is released from the membrane and translocates to the nucleus to induce apoptosis. It acts by binding to Tyr-142-phosphorylated histone H2AX at double-strand breaks (DSBs), recruiting other pro-apoptosis factors such as MAPK8/JNK1. Fe65 is required for histone H4 acetylation at DSBs. Its ability to specifically bind modified histones and chromatin modifying enzymes such as KAT5/TIP60 probably explains the transcription activation activity of Fe65. Fe65 plays a role in the pathogenesis of Alzheimer's disease. It also blocks cell cycle progression by down-regulating thymidylate synthase expression. |
| 适用物种 ： |
H, M, R |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Fe65 protein; Protein Fe65; Amyloid beta A4 precursor protein-binding family B member 1; APBB1; RIR |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/fe65-protein-antibody |
| 标 记 物 ： |
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产品说明 ： |
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