| 克隆类型 ： |
Mouse Monoclonal Antibody |
|
亚 型 ： |
mouse IgG2b |
|
产品描述 ： |
The CD52 (HI186) antibody recognizes a 25-29 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein typically expressed at high levels on thymocytes, lymphocytes, NK cells, monocytes/macrophages. CD52 is expressed at 2% on some granulocytes and epithelial cells of male reproductive tract, and also expressed at variable levels on the majority of lymphoid malignancies, but not on erythrocytes and platelets. A somatic defect in the synthesis of GPI anchors causes a lack of CD52 antigen on cell surface on lymphocytes from patients with paroxysmal nocturnal haemoglobinuria (PNH) . CD52 may be used to diagnose PNH besides CD55 and CD59. All CD52 antibodies are characterized by a strong lytic activity with human complement, irrespective of antibody isotype. |
| 适用物种 ： |
H |
|
应用范围 ： |
E, FC, IHC |
| 应用说明 ： |
Purified antibody is suitable for immunohistochemistry with acetone-fixed frozen and formalin-fixed paraffin sections. E: 1:500-1:1,000; FC: 1:200-1:1,000; IHC: 1:200-1:500 |
| 别 名 ： |
CD52; CAMPATH-1 antigen; Cambridge pathology 1 antigen; Epididymal secretory protein E5; CDw52 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
|
产品文献 ： |
[1] Tadamitsu K et al. eds. 1997. Leucocyte Typing VI: White Cell Differentiation Antigens. P49-52, 113-114 Garland Publishing Inc. New York. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/cd52-hi186-antibody |
| 标 记 物 ： |
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产品说明 ： |
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