| 克隆类型 ： |
Rabbit Polyclonal Antibody |
|
亚 型 ： |
Rabbit Ig |
|
免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the N-term region of human Smad7. |
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产品描述 ： |
Mothers against decapentaplegic homolog 7 (Smad7) is an antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members. Smad7 has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Smad7 functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Smad7 also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Genetic variations in Smad7 influence susceptibility to colorectal cancer type 3 (CRCS3). Colorectal cancer consists of tumors or cancer of either the colon or rectum or both. |
| 适用物种 ： |
H, M, R, B, P |
|
应用范围 ： |
E, WB, IHC |
| 应用说明 ： |
251212 detects both Smad7 and Smad6. E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500 |
| 别 名 ： |
Smad7; Mothers against decapentaplegic homolog 7; Mothers against DPP homolog 7; hSMAD7; MADH7 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 25% glycerol, 1 mg/ml BSA with 0.09% sodium azide. Antibody was purified by Protein-A affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/smad7-antibody |
| 标 记 物 ： |
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产品说明 ： |
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