| 克隆类型 ： |
Rabbit Polyclonal Antibody |
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亚 型 ： |
Rabbit Ig |
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免 疫 原 ： |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human SPRYD2. |
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产品描述 ： |
SPRYD2, also known as Myospryn, was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene. It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle. SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains. SPRYD2 interacts with desmin and calcineurin, and it has been suggested to play a role in the biogenesis of lysosome and negatively regulates slow-fiber-type transformation and skeletal muscle regeneration. SPRYD2 is dysregulated in Duchenne muscular dystrophy. |
| 适用物种 ： |
H, M, R |
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应用范围 ： |
E, WB, IHC, IF |
| 应用说明 ： |
E: 1:500-1:1,000; WB: 1:100-1:500; IF: 1:50-1:200; IHC: 1:100-1:500 |
| 别 名 ： |
SPRY domain-containing protein 2; cardiomyopathy-associated protein 5; CMYA5; dystrobrevin-binding protein 2; DTNBP2; TRIM76; genethonin-3; myospryn; tripartite motif-containing protein 76; C5orf10; SPRYD2 |
|
形 态 ： |
Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) in PBS pH 7.4 with 0.02% sodium azide. Antibody was purified by immunogen affinity chromatography. |
| 保存条件 ： |
Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment. |
| 产品链接 ： |
http://www.abbiotec.com/antibodies/spryd2-antibody |
| 标 记 物 ： |
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产品说明 ： |
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