| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
PhosphoPeptide derived from human TBK1 around the phosphorylation site of Ser172. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
产品描述 ： |
Serine/threonine protein involved in the signaling cascade converging to the activation of the transcription factor NF-kappa-B. May function as an IKK kinase, playing an essential role in the transcription of a subset of TNF-alpha-induced genes. Also mediates production of RANTES/CCL5 and interferon-beta/IFNB1. Has a pivotal role in the innate immune response. Phosphorylates Borna disease virus (BDV) P protein. Phosphorylates and activates IRF3 and IRF7 and allows their nuclear localization. This leads to production of alpha/beta interferons and the development of a cellular antiviral state. It also seems to be a central factor in the induction of the antiviral interferon response. Inhibition of its interaction with IRF3, due to HCV NS3 binding or BDV P protein seems to be one mechanism of inhibition of the innate immune responses of hepatitis C virus (HCV) infection or Borna disease virus infection respectively. Ubiquitous with higher expression in testis. |
| 适用物种 ： |
Hu, Mo, Rat, Chi, Dog, Cow, Hor, |
| 应用说明 ： |
WB: 1:200-1:1000 E: 1:500-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
NAK (phospho S172); Phospho-TBK1/NAK (Ser172); P-TBK1(Ser172); p-NAK(Ser172); TRAF-associated NF-κB kinase; TANK protein; TANK-binding kinase 1; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1; I TRAF; ITRAF; TRAF family member associated NF KAPPA B activator; TRAF family member associated NFKB activator; TRAF interacting protein; TRAF interacting protein TANK isoform a; TRAF interacting protein TANK isoform b; TRAF2. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
|
产品说明 ： |
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