| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
Peptide derived from human TNFSF14. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
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产品描述 ： |
LIGHT protein is a type II transmembrane protein and a tumor necrosis factor (TNF) ligand superfamily member (TNFSF14). LIGHT is expressed on activated T cells and immature dendritic cells and its receptors have been identified as lymphotoxin-Beta receptor (LTBetaR) and the herpesvirus entry mediator (HVEM), both of which lack the cytoplasmic sequence termed as "death domain." LIGHT is first identified as HVEM ligand (HVEM-L) and a deterrent to herpesvirus infection according to its ability to compete with HSV glycoprotein D for HVEM binding. As a T cell-derived costimulatory ligand, TNFSF14 plays a crucial role in T cell activation and proliferation by LIGHT-LTBetaR interaction, and it is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells. Additionally, recent studies also establish a direct role for LIGHT in NK activation/expansion via LIGHT-HVEM interaction, and thus breaking T-cell tolerance at the tumor site. Accordingly, LIGHT is suggested to be involved in CTL-mediated tumor rejection, allograft rejection and graft versus host disease. Although known as lymphotoxin-Gamma, LIGHT plays a minimal role in lymphoid tissue development in contrast with LT-Alpha and Beta. |
| 适用物种 ： |
Hu, Mo, Rat, Dog, Pig, Cow, Hor, |
| 应用说明 ： |
WB: 1:200-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
CD 258; CD258; CD258 antigen; Delta transmembrane LIGHT; Herpes virus entry mediator ligand; Herpesvirus entry mediator A; Herpesvirus entry mediator ligand; herpesvirus entry mediator-ligand; HVEM L; HVEM-L; HVEML; Ligand for herpesvirus entry mediator; LIGHT; LTg; soluble form; TNF14; TNF14_HUMAN; TNFSF 14; TNFSF14; TNFSF14 protein; TR 2; TR2; Tumor necrosis factor (ligand) superfamily, member 14; Tumor necrosis factor ligand superfamily member 14; Tumor necrosis factor ligand superfamily, member 14; Tumor necrosis factor receptor like 2; tumor necrosis factor receptor-like 2; Tumor necrosis factor superfamily member 14; Tumor necrosis factor superfamily member LIGHT. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
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产品说明 ： |
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