| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
Peptide derived from human Aph-1b. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
产品描述 ： |
Anterior pharynx defective 1 (Aph-1) is a polytopic, seven-pass membrane protein that functions as one of the four essential components in the presenilin-Gamma-secretase enzyme complex. This enzyme complex is necessary for the intra-membrane proteolysis of several different membrane proteins, including the beta-Amyloid precursor protein, and is involved in multiple neurodevelopmental signaling pathways. Aph-1b and Aph-1a are splice variants of Aph-1. Aph-1b specifically lacks exon 4, which encodes for the entire fourth transmembrane domain, causing the protein to be destabilized. Deficiency of Aph-1a causes a reduction in Gamma-secretase activity, however deficiency of Aph-1b does not; thus, Aph-1b may execute redundant functions in the cell. |
| 适用物种 ： |
Hu, Mo, Rat, Dog, Pig, Cow, Sheep |
| 应用说明 ： |
WB: 1:200-1:1000 E: 1:500-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
Anterior pharynx defective 1; Anterior pharynx defective 1 homolog B (C. elegans); Anterior pharynx defective 1 homolog B; Anterior pharynx defective 1B like; Anterior pharynx defective 1b short splicing variant; APH 1B; Aph 1beta; APH-1b; Aph-1beta; Aph1 beta; aph1b; APH1B_HUMAN; Aph1beta; Gamma secretase subunit APH 1B; Gamma secretase subunit APH1B; Gamma secretase sununit; Gamma-secretase subunit Aph-1b; Presenilin stabilisation factor like; Presenilin-stabilization factor-like. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
|
产品说明 ： |
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