| 克隆类型 ： |
Rabbit Polyclonal IgG |
|
免 疫 原 ： |
peptide derived from human KMT1B. |
|
纯化方式 ： |
Immunogen affinity purified |
|
缓 冲 液 ： |
PBS, pH 7.4(1%BSA and 0.1% Sodium azide) |
|
产品描述 ： |
Distinct modifications of histone tails, such as acetylation, phosphorylation and methylation, regulate nuclear processes by organizing chromatin into higher order structures. Higher order chromatin influences chromosome function and epigenetic gene regulation. SUV39H2 is a 410 amino acid protein that localizes to the centromere and contains one SET domain, one pre-SET domain, one post-SET domain and one chromo domain. Expressed at high levels in adult testis, SUV39H2 functions as a histone methyltransferase that trimethylates the Lys-9 residue of Histone H3, thereby playing an essential role in establishing constitutive heterochromatin at pericentric and telomere regions. SUV39H2 conveys its enzymatic activity via its multiple catalytic domains, which are necessary for both stable binding of SUV39H2 to chromatin and for SUV39H2 methyltransferase activity. |
| 适用物种 ： |
Hu, Mo, Hor |
| 应用说明 ： |
WB: 1:200-1:1000 IHC: 1:200-1:1000 IF: 1:100-1:500 |
| 别 名 ： |
H3 K9 HMTase 2; Histone H3 K9 methyltransferase 2; Histone lysine N methyltransferase H3 lysine 9 specific 2; Histone lysine N methyltransferase SUV39H2; KMT1B; Lysine N methyltransferase 1B; sSuppressor of variegation 3 9 homolog 2 (Drosophila); Su(var)3 9 Drosophila homolog of 2; Su(var)3 9 homolog 2; Suppressor of variegation 3 9 homolog 2; Suv39h2; SUV92_HUMAN. |
| 保存条件 ： |
Store at -20°C for one year. Avoid repeated freeze-thaw cycles. At 4°C for 2-3 weeks after reconstituted. |
| 标 记 物 ： |
PLLABS公司可供应生物素、辣根过氧化物酶、荧光素标记抗体 |
|
产品说明 ： |
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