|
序 列 ： |
The synthetic peptide used to raise the antibody Cat. No. 250456 is selected from a sequence within the N-term region of human ADAM-TS7. For blocking experiments, a 10 to 100 fold molar excess to antibody is recommended. |
| 分 子 式 ： |
C53H94N26O14
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|
分 子 量 ： |
1319.5 g/mol |
|
纯 度 ： |
Purity > 80% by HPLC |
|
形 态 ： |
Each vial contains 0.1 ml peptide in deionized water for a final concentration of 1 mg/ml. Use at 5.6 ug/ml for a 100X excess over antibody for maximum blocking effect. |
|
溶 解： |
Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
|
保存条件 ： |
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, store at -20°C. |
| 别 名 ： |
A disintegrin and metalloproteinase with thrombospondin motifs 7; ADAMTS-7; ADAM-TS 7; ADAM-TS7; COMPase; ADAMTS7 |
| 产品链接 ： |
http://www.ABBIOTEC.com/peptides/adam-ts7-peptide |
|
产品说明 ： |
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| 产品描述 ： |
A disintegrin and metalloproteinase with thrombospondin motifs 7 (ADAM-TS7) is a metalloprotease that degrades COMP. ADAM-TS7 is up-regulated in articular cartilage and synovium from arthritis patients. The spacer domain and the thrombospondin type-1 domain are important for a tight interaction with the extracellular matrix. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme. |
