产品货号Reference:              CAN-DH-490
检测方法Kit Type:                 Competitive ELISA
规格Kit Size:                         96-well break-apart microplate
灵敏度Sensitivity:                 0.15 ng/mL
检测样本Sample Type:         Human serum / 25 μL
检测范围Calibrator Range:  0.2–40 ng/mL
检测时间Total Assay Time:  75 minutes

背景介绍：

脱氢表雄酮(DHEA)是一种在肾上腺皮质和性腺产生的C19类固醇。DHEA是睾酮和雌激素合成的前体。由于含有17-氧基，DHEA的雄激素活性相对较弱，约为睾酮的10%。然而，在新生儿、青春期儿童和成年妇女中，循环中的DHEA水平可能比睾酮浓度高出几倍，而且外周组织可能迅速转化为更有力的雄激素(雄烯二酮和睾酮)和雌激素。此外，DHEA对性激素结合球蛋白的亲和力较低。这些因素可能增强DHEA的生理活性。
Dehyroepiandrosterone (DHEA) is a C19 steroid produced in the adrenal cortex and to a lesser extent in the gonads. DHEA serves as precursor in testosterone and estrogen synthesis. Due to the presence of a 17-oxo-group, DHEA has relatively weak androgenic activity, which has been estimated at ~10% that of testosterone. However in neonates, peripubertal children and in adult women, circulating DHEA levels may be several fold higher than testosterone concentrations, and rapid peripheral tissue conversion to more potent androgen (androstenedione and testosterone) and estrogen may occur. Moreover, DHEA has relatively low affinity for sex-hormone binding globulin. These factors may enhance the physiologic biopotency of DHEA.