MutS同源物2(MSH2)是一种参与错配修复途径的蛋白。该蛋白通常与遗传性非息肉病性结直肠癌有关，该基因的突变与散发性结直肠癌的发生有关。将抗MSH2与抗MSH6、MLH1和PMS2的抗体配对在IHC面板中时，可优化抗MSH2的使用。报告显示，抗MSH2抗体可用于检测许多正常和肿瘤组织中的MSH2蛋白。

MutS Homolog 2 (MSH2) is a protein involved in the mismatch-repair pathway. This protein is commonly associated with hereditary non-polyposis colorectal cancer, and mutations in this gene are correlated with the development of sporadic colorectal carcinoma. Expression levels of MSH2 are abnormally low in a high percentage of patients with microsatellite instability, as well as endometrial and ovarian cancers. Use of Anti-MSH2 is optimized when paired in an IHC panel with antibodies against MSH6, MLH1, and PMS2. Reports have shown Anti-MSH2 to be useful in the detection of the protein in a number of normal and neoplastic tissues, and for identifying a loss of MSH2 in tumors that are microsatellite-unstable.

 

Clone IHC410

Source Mouse Monoclonal

Positive Control Colon Mucosa, Colon Carcinoma

Dilution Range 1:50-1:200

 

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