配对盒基因8抗体/PAX8 Antibody |
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产品名称 ： 配对盒基因8抗体/PAX8 Antibody
产品类别 ： IVD诊断抗体原料
品 牌 ： GenomeMe
货 号 ： IHC008
规 格 ： 0.1ml/1ml
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详细信息 |
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产品说明 ：
背景描述Description：
Pax-8是(PAX)转录因子家族的一员，是早期发育过程中的关键调节因子。该蛋白参与甲状腺滤泡细胞的发育和甲状腺特异基因的表达，PAX-8基因突变与甲状腺滤泡癌、不典型甲状腺腺瘤和甲状腺发育不全有关。PAX-8蛋白在单纯性卵巢包涵体囊肿和输卵管非纤毛黏膜细胞中表达，而在正常卵巢表面上皮细胞中不表达。Pax-8在正常肺和肺癌组织中也不表达。有报道PAX-8的表达与肾癌、肾母细胞瘤和精原细胞瘤有关，并表明PAX-8可作为诊断肾上皮性肿瘤、卵巢癌和鉴别诊断肺癌和颈部肿瘤的有用标记物。抗PAX-8抗体可用于确定膀胱、肺和乳腺的卵巢微乳头状癌的原发部位，当与一组器官特异性标记物(如尿蛋白原、乳腺球蛋白和TTF-1)联合使用时，抗PAX-8可用于确定卵巢浸润性微乳头状癌的原发部位。
PAX-8 is a member of the paired box (PAX) family of transcription factors, which are key regulators in early development. This protein plays a role in development of thyroid follicular cells and the expression of thyroid-specific genes, with mutations in the PAX-8 gene linked to thyroid follicular carcinomas, atypical thyroid adenomas, and thyroid dysgenesis. The PAX-8 protein is expressed in simple ovarian inclusion cysts and non-ciliated mucosal cells of the fallopian tubes, but is absent from normal ovarian surface epithelial cells. PAX-8 is also not expressed in normal lung or lung carcinomas. Reports have associated PAX-8 expression with renal carcinoma, nephroblastoma, and seminoma, and have indicated PAX-8 as a useful marker for renal epithelial tumors, ovarian cancer, and for differential diagnoses in lung and neck tumors. Anti-PAX-8 can be useful in determining the primary site of invasive micropapillary carcinomas of ovary from bladder, lung, and breast, when used in adjunct with a panel of organ-specific markers such as uroplakin, mammaglobin, and TTF-1.
Specifications：
Clone IHC008
Source Mouse Monoclonal
Positive Control Ovarian Carcinoma (Non-Mucinous Carcinoma), Thyroid Carcinoma, Renal Cell Carcinoma
Dilution Range 1:50-1:200
参考文献References：
Tong GX, et al. Mod Pathol. 2009; 22:1218-27.
Nonaka D, et al. Mod Pathol. 2008; 21:192-200.
Tamara L, et al. Am J Surg Pathol. 2009; 33:1037-41.
Nikiforova MN, et al. Am J Surg Pathol. 2002; 26:1016-23.
Nonaka D, et al. Am J Surg Pathol. 2008; 32:1566-71.
Marques AR, et al. J Clin Endocrinol Metab. 2002; 87:3947-52.
Tina DP, et al. J Biol Chem. 2003; 278:3395-3402.
Bowen NJ, et al. Gynecol Oncol. 2007; 104:331-7.
Zhang P, et al. Pathol Int. 2006; 56:240-245.
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