转录因子SOX10抗体 |
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产品名称 ： 转录因子SOX10抗体
产品类别 ： IVD诊断抗体原料
品 牌 ： GenomeMe
货 号 ： IHC010
规 格 ： 0.1ml/1ml
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背景描述Description：
SRY(性别决定区Y)-框10(Sox-10)，又称转录因子SOx-10，是调节胚胎发育和黑素细胞系细胞分化的核转录因子。SOX-10在神经纤维瘤和神经鞘瘤中广泛表达，SOX-10基因突变与Waardenburg-Shah和Waardenburg-Hirschspung病有关。抗SOX-10抗体被证明对常规的、纺锤形和促纤维增生性黑色素瘤敏感，并被用于检测前哨淋巴结中的转移性黑色素瘤和淋巴结包膜痣。
SRY (Sex Determining Region Y)-Box 10 (SOX-10), also known as transcription factor SOX-10, is a nuclear transcription factor that acts in regulation of embryonic development and in the specification and differentiation of cells of melanocytic lineage. SOX-10 is diffusely expressed in neurofibromas and schwannomas, and mutations in the SOX-10 gene are linked to Waardenburg-Shah and Waardenburg-Hirschsprung disease. Anti-SOX-10 has been shown to be sensitive for conventional, spindled, and desmoplastic melanoma, and has been used to detect metastatic melanoma and nodal capsular nevus in sentinel lymph nodes.
Specifications：
Clone IHC010
Source Mouse Monoclonal
Positive Control Melanoma, Skin Melanocytes
Dilution Range 1:50-1:200
参考文献References：
Pingault V, et al. Nat Genet. 1998; 18:171-3.
Bondurand N, et al. Hum Mol Genet. 2000; 8:1785-9.
Kelsch RN. BioEssays. 2006; 28:788.
Nonaka D, et al. Am J Surg Pathol. 2008; 32:1291-8.
Chorny JA, et al. Am J Dermatopathol. 2002; 24:309-12.
Robson A, et al. Histopathology. 2001; 38:135-40.
Longacre T, et al. Am J Surg Pathol. 1996; 20:1489-500.
Ramos-Herberth FI, et al. J Cutan Pathol. 2010; 37:944–52.
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